What are the side effects of the tetanus shot?

Tetanus is a serious disease that can be prevented by getting the tetanus shot. There are several different types of vaccines that protect against tetanus, and they are often combined with components that protect us against other diseases as well. This helps reduce the number of shots an individual needs in a single visit. These vaccines include diphtheria, tetanus and pertussis (DTaP); tetanus, diphtheria and pertussis (Tdap); and tetanus and diphtheria (Td) vaccines. Babies and children younger than age 7 receive DTaP while older children and adults receive Tdap or Td. 

Your healthcare provider will help determine which vaccine is best for you based on your age and any history of an allergic reaction to one or more of the vaccines or its components. For example, if you have experienced a serious reaction to a pertussis-containing vaccine, your healthcare provider may recommend you receive the Td vaccine instead. 

Side effects of the tetanus vaccines are possible, but they are generally mild when they do occur.

It is common to experience some pain or discomfort while the tetanus shot is given. Like other shots, there could be pain, redness or swelling where the tetanus shot was given. Adults normally get a tetanus shot in the shoulder muscle. Children normally get the tetanus shot in the arm or thigh.

Adults and children may experience some side effects after getting a tetanus shot. They’re usually mild and go away in a few days. Side effects may include:

• Soreness, redness or swelling where the tetanus shot was given (injection site)
• Mild fever and chills
• Headache
  
• Muscle weakness or body ache
• Feeling tired
• Upset stomach, nausea, vomiting or diarrhea
• Not feeling hungry
  
• Fussing (in children)

In rare instances, the DTaP shot can cause more serious reactions in children including:

• Seizures
• Nonstop crying, for three hours or more
  
• High fever (over 105°F)
• Swelling of the entire arm or leg where the shot was given

No, you cannot get tetanus from the tetanus shot. The tetanus vaccine helps protect against tetanus.

As with any vaccine or medication, there is a very small chance of a tetanus shot causing a severe allergic or other significant reaction.

Signs of a severe allergic reaction include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness or weakness. An allergic reaction could occur after someone receives a shot and then leaves the clinic or pharmacy. If any of these symptoms occur, call 911 and seek immediate emergency care.

It is important to tell your healthcare provider if you or your child have ever had any allergic or unusual reaction to any vaccine.

Clinically reviewed and updated by Rebeca Thomas, RN, BSN, February 2025.